Pharmacological Effects Naproxen 550 mg:
Derivative of propionic acid. Has a marked anti-inflammatory, analgesic and antipyretic effect. The mechanism of drug action is inhibition of leukocyte migration, reducing the activity of lysosomal and inflammatory mediators. Naproxen Acre is a strong inhibitor of lipoxygenase, blocks the synthesis of arachidonic acid. In addition, naproxen Acre inhibits the activity of cyclooxygenase-arachidonic acid, which leads to inhibition of prostaglandin synthesis intermediates. Inhibits platelet aggregation.
Pharmacokinetics Naproxen 550 mg
After oral naproxen is rapidly and almost completely absorbed from the gastrointestinal tract. The maximum plasma concentration is reached within 2-4 h. Plasma protein binding – 99%. Distinguished mainly by the kidneys. Half Life – 12-15 hours
Indications Naproxen 550 mg:
Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, gouty arthritis, ankylosing spondylitis (ankylosing spondylitis), osteoarthritis. Pain syndrome: myalgia, ossalgiya, neuralgia, arthralgia, sciatica, headache, toothache pain, tendinitis, in oncology, post-traumatic and postoperative pain accompanied by inflammation, algomenorrhea, adnexitis, childbirth (as analgesic and tokoliticheskogo means). Infectious-inflammatory diseases of ENT organs with marked pain syndrome (in the combined therapy): pharyngitis, tonsillitis, otitis media. Febrile syndrome with “cold” and infectious diseases.
How to use Naproxen 550 mg:
Inside. Tablets should be taken as a whole, washed down with a liquid, can be taken with food. In the acute stage – at 0.5-0.75 g, 2 times per day. The maximum daily dose – 1.75 was for maintenance therapy – mean daily dose of 500 mg in 2 divided doses (morning and night). When an acute attack of gout, the first dose – 825 mg, then – 275 mg every 8 h. algodismenoree – in the first dose of 500 mg, then 275 mg every 6-8 hours for 3-4 days. Migraine – 500 mg. Rectal suppositories is usually prescribed at night (1 candle, 0.5 g). If necessary, use of naproxen in high doses can be combined in the appointment of candles and tablets. Children aged 1 to 5 years – a daily dose of 2.5-5 mg / kg in 1-3 doses; treatment should not exceed 14 days. In juvenile arthritis in children older than 5 years of daily dose – 10 mg / kg. The preferred dosage form for children is a suspension.
Side effects Naproxen 550 mg:
NSAID gastropathy (gastric antral damage in the form of erythema mucosal hemorrhages, erosions and ulcers). Nausea, vomiting, epigastric discomfort, skin rash, urticaria, angioedema, headache, drowsiness, tinnitus, dizziness, weakness, slow reaction rate; erosive and ulcerative lesions, etc. GI, gastrointestinal bleeding and perforation, eosinophilic pneumonia; thrombocytopenia, granulocytopenia, aplastic anemia, hemolytic anemia, hearing loss, impaired renal function or pecheni.Peredozirovka. Symptoms: heartburn, indigestion, nausea, vomiting, drowsiness. Treatment: gastric lavage, activated charcoal – 0.5 g / kg. Dialysis is ineffective.
Contraindications Naproxen 550 mg:
Hypersensitivity, erosive and ulcerative lesions of the gastrointestinal tract (in acute phase), “Aspirin” triad (a combination of asthma, recurrent polyposis of the nose and paranasal sinuses and ASA intolerance and drug pyrazolone series), inhibition of bone marrow hematopoiesis, and hepatic or renal insufficiency, pregnancy, Lactation, Infancy (under 1 year). C care. CHF, children’s age (16 years).
Drug Interactions Naproxen 550 mg:
With the simultaneous appointment may cause a decrease diuretic effects of furosemide, increased the effect of indirect anticoagulants. Increases the toxicity of phenytoin, sulfonamides, methotrexate (blocks tubular secretion). Reduces the hypotensive effect of beta-blockers. Reduces the excretion of Li + and increases its concentration in plasma. Antacid medicines containing Mg2 + and Al3 +, reduces the absorption of naproxen. Myelotoxic drugs increase gematotoksichnosti manifestations of the drug.
Overdose Naproxen 550 mg
Symptoms: drowsiness, heartburn, indigestion, nausea, and vomiting.
Treatment: gastric lavage, the introduction of activated charcoal – 0.5 g / kg; dialysis is not effective.
Extras:
Precautions.
With prolonged use is necessary to control the function of liver and kidney of the peripheral blood.
Special instructions.
If necessary, the definition of 17-ketosteroids or 5-oxyindoleacetic acid should be discontinued treatment for 48 h before the study.
Attention!
Before using the drug naproxen should consult with your doctor. This instruction is given a free transfer and is intended solely for information. For more information, please contact the manufacturer annotations.
